Halogenated Trityl Cations as Easy-to-Access Super Electrophiles.

Herein, we present the easy-to-access synthesis of the perfluorotrityl cation (15F) with commercial GaCl and the further functionalization of the para-fluorine atoms of 15F via halodefluorination using trimethylsilyl halides TMSX (X=Cl, Br). This gives access to equally reactive halogenated trityl derivatives (p-3Cl12F and p-3Br12F), which can be handled at room temperature. The impact of the para-exchange on the electronic structure is determined by NMR and UV/Vis spectroscopy.

Sustained Disease Control in DME Patients upon Treatment Cessation with Brolucizumab.

Treatment cessation due to a dry retina has not been systematically addressed in diabetic macular edema (DME). In three out of four patients receiving 6 mg of brolucizumab in the KITE study, treatment was terminated after the study ended. The KITE study was a double-masked, multicenter, active-controlled, randomized trial (NCT03481660) in DME patients.

Unravelling highly oxidized nickel centers in the anodic black film formed during the Simons process by X-ray absorption near edge structure spectroscopy.

The Simons process is an electrochemical fluorination method to prepare organofluorine compounds. Despite the wide application, the underlying mechanism is still unclear. We report the investigation of the black film formed on the surface of the anodes in aHF by an Ni K-edge X-ray absorption near edge structure (XANES) investigation.

Circulating cell-free DNA-based biomarkers for prognostication and disease monitoring in adrenocortical carcinoma.

Objective: Adrenocortical carcinoma (ACC) is a rare aggressive cancer with heterogeneous behaviour. Disease surveillance relies on frequent imaging, which comes with significant radiation exposure. The aim of the study was to investigate the role of circulating cell-free DNA (ccfDNA)-related biomarkers (BMs) for prognostication and monitoring of ACC.

Adjusting surface coverage of Pt nanocatalyst decoration for selectivity control in CMOS-integrated SnO thin film gas sensors.

Smart gas-sensor devices are of crucial importance for emerging consumer electronics and Internet-of-Things (IoT) applications, in particular for indoor and outdoor air quality monitoring (, CO levels) or for detecting pollutants harmful for human health. Chemoresistive nanosensors based on metal-oxide semiconductors are among the most promising technologies due to their high sensitivity and suitability for scalable low-cost fabrication of miniaturised devices. However, poor selectivity between different target analytes restrains this technology from broader applicability.