Publications by authors named "S Stefanos"
Background: Midazolam (MZ) is commonly used in critically ill neurosurgical patients. Neuro-penetration of MZ and its metabolite, 1-hydroxy-midazolam (1-OH-MZ), is not well characterized.
Objective: This study evaluated correlations between serum and cerebrospinal fluid (CSF) concentrations of MZ and 1-OH-MZ and assessed implications on patient sedation.
Article Synopsis
- - Eravacycline, a new tetracycline antibiotic, has been linked to cases of pancreatitis, with this being the first documented instance associated specifically with it.
- - A 46-year-old male developed symptoms of pancreatitis, including abdominal pain and elevated lipase levels, after receiving eravacycline for a perirectal abscess.
- - Clinicians should be cautious and avoid prescribing eravacycline to patients with risk factors for pancreatitis, and they should consider this condition if patients on the drug report relevant symptoms.
Background: Data are limited regarding use of piperacillin/tazobactam for ESBL urinary tract infections (UTIs). The objective of this study was to compare clinical outcomes of patients treated empirically with piperacillin/tazobactam versus carbapenems for ESBL UTIs.
Methods: This retrospective, observational, propensity score-matched study evaluated adults with an ESBL on urine culture.
Extravasation is the leakage of intravenous solutions into surrounding tissues, which can be influenced by drug properties, infusion techniques, and patient-related risk factors. Although peripheral administration of vesicants may increase the risk of extravasation injuries, the time and resources required for central venous catheter placement may delay administration of time-sensitive therapies. Recent literature gathered from the growing use of peripheral vasopressors and hypertonic sodium suggests low risk of harm for initiating these emergent therapies peripherally, which may prevent delays and improve patient outcomes.
View Article and Find Full Text PDFStudy Objective: Although fluid resuscitation is recommended by the Society of Critical Care Medicine Surviving Sepsis Campaign Guidelines, risks of volume overload persist.The objective of this systematic review is to assess the effects of a restrictive fluid resuscitation approach in the septic patient both during and after the initial resuscitation period (30 ml/kg).
Design: A systematic review and meta-analysis with trial sequential analysis (TSA) of randomized controlled trials was conducted.