Enhanced functionality and migration of human gingival fibroblasts on vacuum ultraviolet light-treated titanium: An implication for mitigating cellular stress to improve peri-implant cellular reaction.

Purpose: The maintenance of peri-implant health relies significantly on the integrity of the peri-implant seal, particularly vulnerable at the interface between implant abutment and soft tissue. Early healing stages around implants involve cellular exposure to oxidative stress. This study aimed to investigate whether vacuum ultraviolet (VUV)-treated titanium augments the growth and functionality of human gingival fibroblasts while mitigating cellular stress.

MARCH2, a T cell specific factor that restricts HIV-1 infection.

Membrane-associated RING-CH (MARCH) 2 is a member of the MARCH protein family of RING-CH finger E3 ubiquitin ligases that play important roles in regulating the levels of proteins found on the cell surface. MARCH1, 2 and 8 inhibit HIV-1 infection by preventing the incorporation of the envelope glycoproteins into nascent virions. However, a better understanding of the mechanism utilized by MARCH proteins to restrict HIV-1 infection is needed.

Enhancing Maritime Cybersecurity through Operational Technology Sensor Data Fusion: A Comprehensive Survey and Analysis.

Cybersecurity is becoming an increasingly important aspect in ensuring maritime data protection and operational continuity. Ships, ports, surveillance and navigation systems, industrial technology, cargo, and logistics systems all contribute to a complex maritime environment with a significant cyberattack surface. To that aim, a wide range of cyberattacks in the maritime domain are possible, with the potential to infect vulnerable information and communication systems, compromising safety and security.

SARS-CoV-2 ORF7a Mutation Found in BF.5 and BF.7 Sublineages Impacts Its Functions.

A feature of the SARS-CoV-2 Omicron subvariants BF.5 and BF.7 that recently circulated mainly in China and Japan was the high prevalence of the ORF7a: H47Y mutation, in which the 47th residue of ORF7a has been mutated from a histidine (H) to a tyrosine (Y).

Human Gingival Fibroblast Growth and Function in Response to Laser-Induced Meso- and Microscale Hybrid Topography on Dental Implant Healing Abutments.

Purpose: To examine the behavior and function of human gingival fibroblasts growing on healing abutments with or without laser-textured topography.

Materials And Methods: Human primary gingival connective tissue fibroblasts were cultured on healing abutments with machined or laser-textured (Laser-Lok, BioHorizons) surfaces. Cellular and molecular responses were evaluated by a variety of tests, including cell density assay (WST-1), fluorescence microscopy, real-time quantitative reverse-transcription polymerase chain reaction (qRT-PCR), and detachment tests.