Pediatric diffuse intrinsic pontine gliomas- a prospective observational study from a tertiary care neurosurgical center.

Introduction: Diffuse intrinsic pontine glioma (DIPG) in children comprises 80% of brainstem gliomas. In 2021, 5th edition of WHO CNS tumor classification defined H3K27M altered diffuse midline gliomas (DMGs) which replaced this entity. Lesion location precludes resection and the only current option available is radiotherapy.

The Role of Snake Venom Proteins in Inducing Inflammation Post-Envenomation: An Overview on Mechanistic Insights and Treatment Strategies.

The intricate combination of organic and inorganic compounds found in snake venom includes proteins, peptides, lipids, carbohydrates, nucleotides, and metal ions. These components work together to immobilise and consume prey through processes such as paralysis and hypotension. Proteins, both enzymatic and non-enzymatic, form the primary components of the venom.

Single oral dose of gabapentin reduces vigilance and increases play behavior without changing mobility in New Zealand white rabbits (Oryctolagus cuniculus).

Objective: To evaluate rabbit behavioral responses and activity after gabapentin administration.

Methods: In this study, 5 intact female and 3 intact male New Zealand white rabbits aged 8 to 12 months were administered a single oral 25-mg/kg dose of gabapentin. This study was conducted from December 2020 to February 2021.

Enhancing Clinical Trial Efficiency: The Impact of a Dual Digital Alert System on Quantitative Imaging Report Turnaround Time.

Objective: This study aimed to assess the effectiveness of a dual digital alert system and automatic radiologist reassignment in improving the efficiency of quantitative imaging report delivery for clinical trials.

Materials And Methods: Assessing tumor metrics is critical to oncologic disease management, informed treatment planning, and for monitoring therapeutic response and even more so in cancer clinical research trials. A collaborative effort with the Institutional Research Information Systems division led to developing a web-based system with a Java backend, tested using Agile methodology to improve patient care with improved turnaround time (TAT) of quantitative reports.

Demodex and the eye - A review.

Demodexblepharitis (DB) has become one of the common differential diagnoses in patients presenting with red eyes in daily clinics. In this review article, we have incorporated a detailed discussion about the mite and the various mechanisms by which it causes different signs and symptoms, the risk factors, and diagnostic methods with current and emerging treatment modalities. Because of the chronic symptoms and rather a late diagnosis, DB considerably affects patients' quality of life.