Publications by authors named "S Spivack"
Article Synopsis
- Basal cells (BCs) are important for regenerating damaged airways but can transform into cancerous cells in smokers; this study investigates BC growth in smokers and non-smokers without cancer, as well as in those with lung cancer.
- Researchers used techniques like RNA sequencing and flow cytometry to analyze BCs from endobronchial samples, focusing on differences in cell growth, shape, and molecular characteristics between various donor groups.
- Results showed that smoking decreased BC proliferation, increased abnormal cell shapes in certain cancers, and highlighted changes in gene expression linked to cell behavior and signaling pathways that may contribute to early lung cancer development.
Lung diseases, including lung cancer, are rising causes of global mortality. Despite novel imaging technologies and the development of biomarker assays, the detection of lung cancer remains a significant challenge. However, the lung communicates directly with the external environment and releases aerosolized droplets during normal tidal respiration, which can be collected, stored and analzsed as exhaled breath condensate (EBC).
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- - A case of tinea genitalis was reported in an immunocompetent woman in Pennsylvania, caused by Trichophyton indotineae, likely from sexual contact.
- - The infection showed resistance to terbinafine, the standard antifungal treatment, but responded positively to itraconazole.
- - It's important for healthcare providers to recognize T. indotineae as a possible cause of antifungal-resistant genital infections.
Article Synopsis
- * EBC contains a wide range of tiny compounds, such as proteins, metabolites, and nucleic acids, but their low concentrations present significant analysis challenges.
- * Advances in breath collection technology and improved mass spectrometry have drastically increased the sensitivity of EBC analysis, promoting growth in research on breath biomarkers.*
Purpose: In this systematic review, the authors examine the prevalence and extent of stigmatizing attitudes among health care professionals (HCPs) and trainees against patients with substance use disorders (SUDs), including research on interventions to reduce stigma.
Method: The authors searched 7 databases for articles published from January 1, 2011, through February 15, 2023, that quantified SUD stigma among HCPs or trainees. Inclusion criteria allowed both observational and intervention studies from the United States or Canada to be included in this review.