Publications by authors named "S Speca"
Introduction: Inflammatory bowel diseases (IBDs) are chronic immune driven intestinal disorders with marked metabolic alteration. Mass spectrometry imaging (MSI) enables the direct visualization of biomolecules within tissues and facilitates the study of metabolic changes. Integrating multiple spatial information sources is a promising approach for discovering new biomarkers and understanding biochemical alteration within the context of the disease.
View Article and Find Full Text PDFThe therapeutic management of Crohn's disease (CD), a chronic relapsing-remitting inflammatory bowel disease (IBD), is highly challenging. Surgical resection is sometimes a necessary procedure even though it is often associated with postoperative recurrences (PORs). Tofacitinib, an orally active small molecule Janus kinase inhibitor, is an anti-inflammatory drug meant to limit PORs in CD.
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- * In a study using a mouse model, IVIg was found to effectively prevent skin inflammation and fibrosis by decreasing immune cell infiltration and lowering levels of specific proinflammatory cytokines and fibrosis markers.
- * While IVIg could reduce skin and dermal thickness when given as treatment, its effects on skin inflammation and established fibrosis were less clear, suggesting that more research is needed to explore the timing and frequency of IVIg administration in SSc patients.
Article Synopsis
- Systemic sclerosis (SSc) is an autoimmune disease with few treatment options, making the development of new therapies essential.
- Researchers focused on galectin-3 (Gal-3), a protein linked to SSc, and found significant transcriptomic markers in patient blood samples that correlate with disease severity and complications.
- They created monoclonal antibodies that target Gal-3, which showed promise in a mouse model by reducing skin and lung damage and reversing adverse gene expression changes associated with SSc, highlighting potential for new treatment strategies.
Background: Postoperative recurrence (POR) after ileocecal resection (ICR) affects most Crohn's disease patients within 3-5 years after surgery. Adherent-invasive (AIEC) typified by the LF82 strain are pathobionts that are frequently detected in POR of Crohn's disease and have a potential role in the early stages of the disease pathogenesis. CNCM I-3856 is a probiotic yeast reported to inhibit AIEC adhesion to intestinal epithelial cells and to favor their elimination from the gut.
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