Publications by authors named "S Spandorfer"
Article Synopsis
- A CRESS-DNA virus, primarily found in fecal samples from vertebrates, was examined in human vaginal samples for its presence.
- Viral metagenomics was conducted on samples from 28 healthy women in NYC, with some providing duplicates over a 12-21 day span.
- The study found that one individual had continuous detection of the CRESS-DNA virus over a twelve-day period, indicating it can persist in the human vagina.
Article Synopsis
- * Out of 29 women studied, 18 tested positive for HPV, showing a significant increase from initial visits to after hormone stimulation.
- * Analysis identified various HPV types, notably under two genera, with some sequences potentially representing new types.
Objective: To determine the optimal number of fresh donor oocytes to expose to sperm for patients who want to prioritize reducing surplus embryos while preserving the live birth rate.
Design: Cross-sectional study.
Setting: University.
Article Synopsis
- The Phylum Cressdnaviricota includes various circular Rep-encoding single-stranded (CRESS)-DNA viruses, which are found widely in many eukaryotes, but their presence in humans is not well-studied.
- A study collected vaginal swabs from 28 women aged 29 to 43 at a fertility clinic in NYC to investigate CRESS-DNA viruses' prevalence and genetic diversity.
- The analysis identified 11 nearly complete viral genomes in 16 women, revealing one sequence classified as Gemycircularvirus and ten as previously unclassified, suggesting that novel CRESS-DNA viruses may exist in the vaginal microbiome with uncertain clinical implications.
Problem: The association of viruses with infertility remains incompletely evaluated.
Method Of Study: Vaginal secretions from 46 women seeking treatment in the Center for Reproductive Medicine and Infertility at Weill Cornell Medicine were tested for viruses by metagenomic analysis by lab personnel blinded to all clinical data.
Results: Torquetenovirus (TTV) was identified in 16 women, alphapapillomavirus in seven women and most were positive for bacteriophages.