Publications by authors named "S Soushi"

Article Synopsis
  • This study analyzed 13 eyes from 9 patients with intraocular lymphoma over 15 years, noting that inflammation in the front of the eye was generally mild or absent.
  • Unlike previous beliefs that this condition mimics uveitis, fundus images showed tumor-like lesions indicating the presence of tumor cell growth rather than just inflammation.
  • The study highlights the need for early diagnosis and treatment due to the poor prognosis for patients and the disease's responsiveness to radiation therapy.
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Article Synopsis
  • Double infection with two herpes simplex virus strains showed decreased effectiveness of interferon (IFN) in inhibiting virus growth.
  • By analyzing genetic recombinants from these infections, researchers identified that two specific genetic regions were linked to IFN resistance in the virus.
  • Further experimentation revealed that the BglII-N fragment of HSV-2 was crucial for maintaining IFN resistance, as it improved the virus's ability to grow in IFN-treated environments.
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A retinal pigment epithelial (RPE) cell line (K-1034) was examined for its susceptibility to human herpesvirus 6 variant A (HHV-6A). Exposure of K-1034 cells to HHV-6A induced the formation of multinucleated giant cells, which was suppressed by an inhibitor of viral DNA synthesis. In the giant cells, herpesvirus nucleocapsids were demonstrated by electron microscopy and the viral glycoprotein B was detected by immunofluorescence assay.

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Although human cytomegalovirus (HCMV) predominantly infects epithelial cells in vivo, the majority of studies of HCMV gene expression and replication have been conducted using non-epithelial cell lines in part because of the absence of a good experimental system using epithelial cells. To address the nature of epithelial cell infection, we investigated the susceptibility of an epithelial cell line (K-1034) established from the retinal pigment epithelium to HCMV infection. This cell line exhibited high susceptibility to HCMV, as evidenced by detection of one of the immediate early antigens, IE2, in the nuclei of more than 80% of K-1034 cells at 24 h following inoculation at a multiplicity of infection of 3 plaque forming units per cell.

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The risk factors of retinopathy associated with administration of interferon have not been fully clarified. We prospectively examined the retinal condition in 50 patients with type C chronic active hepatitis during alpha-interferon treatment. 43 patients (86%) were shown to have retinopathy during the course of interferon treatment, and were divided into three groups.

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