Publications by authors named "S Soma"
Article Synopsis
- * Researchers discovered that dopamine neurons that connect to the lateral EC (LEC) become dysfunctional in early AD, leading to memory issues.
- * By using optogenetics and L-DOPA treatment to reactivate these dopamine fibers, they were able to improve memory function in mouse models, highlighting the potential for targeting LEC dopamine in AD treatment.
Article Synopsis
- Liquid biopsy (LB) is a minimally invasive method for analyzing tumor-derived materials, and this study explores the potential of bile as a superior source of cell-free DNA (cfDNA) compared to plasma for detecting mutations in biliary tract cancers.
- The research involved collecting cfDNA from the bile of 24 cancer cases, including various types of biliary tract cancers, and applying a multigene panel to identify cancer driver mutations.
- Results indicated that bile yielded a higher detection rate of cancer driver mutations, with 54% of bile samples testing positive compared to just 17% of plasma samples, highlighting bile's effectiveness for liquid biopsy analysis.
Characteristics of falls in Japanese community-dwelling older adults.
Geriatr Gerontol Int
November 2024
Objective: Understanding the characteristics of falls among older adults is necessary to prevent them. These characteristics include questions such as when (month and time), where (places), who (age), what (injury), why (trigger), and how (direction) the falls occur. The objective of this study was to identify the characteristics of falls in individuals aged 65-74 years (young-old), 75-84 years (old-old), and ≥85 years (oldest-old).
View Article and Find Full Text PDFTo understand the physiological mechanisms by which pituitary-derived gonadotropins (Gths), follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh) regulate asynchronous oocyte development, we investigated the function and expression of Fsh and Lh receptors (Fshr and Lhr, respectively) in Pacific bluefin tuna (PBT, Thunnus orientalis). As a first, we cloned the full-length cDNAs encoding PBT Fshr and Lhr. Recombinant PBT Fsh and Lh single-chain proteins were produced in abundance using stable CHO-DG44 cell lines and were subsequently purified from the culture medium, culminating in their yields being 87.
View Article and Find Full Text PDFArticle Synopsis
- Visudyne is the only approved nanomedicine for photodynamic therapy, using a stable form of the drug BPD conjugated to a specific lysophospholipid, BPD-PC, which effectively targets cancer cells.
- The study compares BPD-PC incorporated in solid lipid nanoparticles (similar to the Spikevax vaccine) against traditional liposomal formulations, revealing that the solid lipid nanoparticles generate more singlet oxygen and maintain better stability by significantly reducing the leaching of BPD-PC.
- Despite different chemical properties, both formulations showed similar cellular uptake and phototoxicity against pancreatic cancer cells, but the solid lipid nanoparticles enhanced immunogenic cell death more effectively, suggesting potential for improved cancer therapies.