Publications by authors named "S Soeda"
: The usefulness of bevacizumab (BEV) as first-line chemotherapy for advanced ovarian clear cell carcinoma (CCC) was retrospectively evaluated at Tohoku Gynecologic Cancer Unit institutions. : A total of 81 patients (52 patients without BEV and 29 with BEV) with advanced ovarian CCC who received initial platinum-based chemotherapy were enrolled. We selected 26 patients each without and with BEV according to propensity score matching methods, and compared the platinum-resistant recurrence rate, response rate, progression-free survival (PFS), overall survival (OS), and adverse events between the two groups.
View Article and Find Full Text PDFArticle Synopsis
- Foraminal stenosis is a type of lumbar spinal stenosis that can be treated with full-endoscopic spine surgery (FESS), especially in patients with stable isthmic spondylolisthesis at L5.
- The article outlines the process for achieving complete decompression, emphasizing the importance of visualizing the "pars crisscross" structure during the procedure.
- The step-by-step method involves docking an 8 mm cannula, removing specific bone structures, and confirming decompression of the L5 nerve root, making it the first detailed guide for this surgery under local anesthesia.
Article Synopsis
- Development of chemotherapy-induced peripheral neuropathy (CIPN) can complicate cancer treatment, leading to dose reductions or stopping therapy; Goshajinkigan (GJG), a traditional Japanese medicine, may help reduce these symptoms.
- A study with 55 ovarian cancer patients tested two groups: one started GJG after experiencing grade 2 neuropathy, while the other took it a week before chemotherapy; the main goals were to assess sensory neuropathy severity and pain levels.
- Results showed that patients starting GJG early (Group B) had fewer pain complaints, lower reliance on pain medications, and less persistent neuropathy six months later, suggesting that preventive use of GJG could be beneficial, but more research is needed for confirmation
Upregulation of nuclear factor κB (NFκB) signaling is a hallmark of aging and a major cause of age-related chronic inflammation. However, its effect on cellular senescence remains unclear. Here, we show that alteration of NFκB nuclear dynamics from oscillatory to sustained by depleting a negative feedback regulator of NFκB pathway, NFκB inhibitor alpha (IκBα), in the presence of tumor necrosis factor α (TNFα) promotes cellular senescence.
View Article and Find Full Text PDFArticle Synopsis
- Stage IVA cervical cancer invades nearby organs like the bladder or rectum, making it challenging to treat, with concurrent chemoradiotherapy usually recommended.
- A 51-year-old woman with advanced cervical cancer received neoadjuvant chemotherapy (paclitaxel and cisplatin), which significantly reduced her tumor size.
- After successful surgery to remove the tumor and additional chemotherapy, the patient remained alive and disease-free 33 months later, suggesting that aggressive treatment may be effective for this cancer stage.