Publications by authors named "S Soda"
There is no established treatment for lung adenocarcinoma with uncommon/compound epidermal growth factor receptor (EGFR) mutations. We report a case of a 73-year-old man with stage IVB lung adenocarcinoma harboring E709G and L861Q EGFR mutations. After 2 months of afatinib treatment, significant tumor shrinkage was observed, and the patient's condition remained stable for 1 year.
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- Immune checkpoint inhibitors (ICIs) are standard treatment for advanced non-small cell lung cancer (NSCLC), and this study investigates the impact of upfront radiotherapy for brain metastases (BMs) in patients treated with either ICI alone or ICI plus chemotherapy.
- An analysis of 591 patients across multiple institutions revealed that those receiving upfront radiotherapy alongside ICI alone had significantly longer overall survival compared to those who did not receive radiotherapy.
- However, in the group treated with ICI-chemo, the addition of upfront radiotherapy did not show any significant survival benefit, suggesting different responses to treatment strategies.
Article Synopsis
- - The study examined the safety of re-administering EGFR-tyrosine kinase inhibitors (TKIs) in patients who had experienced pneumonitis from osimertinib, particularly focusing on the risk of recurrent pneumonitis.
- - Out of 124 patients treated, 54.8% underwent EGFR-TKI rechallenge, with a 27% recurrence rate of pneumonitis within 12 months, showing that patients on osimertinib had a significantly higher risk of recurrence compared to those on older EGFR-TKIs.
- - Findings indicate that osimertinib leads to higher rates of recurrent pneumonitis upon rechallenge compared to traditional EGFR-TKIs, suggesting more caution is
Background: Bronchoscopy is a relatively invasive procedure where patients are often sedated. However, adequate sedation is not always achieved. Propofol is often used for difficult-to-sedate patients undergoing bronchoscopy despite a potential risk of respiratory depression.
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