Publications by authors named "S Sobieszczyk"
Objective: The primary pathologic reason for thrombotic thrombocytopenic purpura (TTP) lies in the systemic formation of platelet aggregations in association with endothelial cells damage. Endothelial damage is a result of an abnormal synthesis and metabolism of unusually large von Willebrand Factor (ULvWF) multimers. In normal conditions vWF cleaving metalloprotease, known as ADAMTS-13 (A Disintegrin And Metalloproteinase with Thrombospondin type-1 motif, member 13) prevents the ULvWF entrance in the circulation.
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- Exsanguination is a significant yet often overlooked factor leading to treatment failures in trauma and surgical patients, particularly those without prior blood clotting disorders.
- The study aimed to evaluate the effectiveness of various interdisciplinary treatment strategies based on expert opinions regarding massive bleeding.
- Key findings highlight that severe blood loss, excessive fluid therapy, and inadequate blood product administration increase the risk of post-hemorrhagic coagulopathy, while treatments like antifibrinolytic drugs and specific coagulation factor concentrates are recommended for effective management.
Article Synopsis
- During pregnancy, increased coagulation factor levels create a "physiological" hypercoagulability, beneficial for preventing hemorrhage during delivery but raising the risk of venous thrombosis.
- Antithrombin, a key inhibitor of coagulation, can become deficient due to various conditions, leading to increased thrombosis risk, either acquired or inherited.
- The study discusses the case of a pregnant woman with deep vein thrombosis and antithrombin deficiency while examining the potential benefits of routine antithrombin testing and supplementation, especially for obese women, highlighting the lack of established guidelines for treatment.
Thrombophilia is a congenital or acquired disorder of haemostatic imbalance leading to clot formation. Congenital thrombophilia is a result of different genetic polymorphisms in the genes coding for particular elements in coagulation and fibrinolysis processes and is connected with excessive readiness to thrombosis in the carriers the mutated alleles. A higher coagulation activity has been observed in case of pregnant women who are carriers of congenital thrombophilia, when compared to the pre-pregnancy activity.
View Article and Find Full Text PDFBackground: This paper presents an analysis of 25 patient cases in which recombinant factor VIIa was used in the management of postpartum hemorrhage, including severe and/or life-threatening bleeds. Anecdotal experiences in the empirical use of this agent are described and dosing regimens, effects on bleeding, and safety data are presented.
Methods: Data were extracted from the international, internet-based, voluntary registry, haemostasis.