Publications by authors named "S Skokic"
Article Synopsis
- The bradykinin type 2 receptor plays a key role in the body's response to acute ischemic injury, but its effects during the chronic phase are not well understood.
- Research using bradykinin type 2 receptor knockout mice revealed that while receptor deficiency reduced early vascular permeability in the brain, it led to worse outcomes in the chronic phase, including more neuronal loss and functional deficits.
- The study suggests that targeting the bradykinin type 2 receptor could offer therapeutic benefits during the later stages of ischemic injury, as the receptor has different impacts at various stages of the condition.
Introduction: Magnetic resonance imaging (MRI) is invaluable for understanding brain disorders, but data complexity poses a challenge in experimental research. In this study, we introduce suMRak, a MATLAB application designed for efficient preclinical brain MRI analysis. SuMRak integrates brain segmentation, volumetry, image registration, and parameter map generation into a unified interface, thereby reducing the number of separate tools that researchers may require for straightforward data handling.
View Article and Find Full Text PDFProgrammed cell death or apoptosis is a critically important mechanism of tissue remodeling and regulates conditions such as cancer, neurodegeneration or stroke. The aim of this research article was to assess the caged Z-DEVD-aminoluciferin substrate for in vivo monitoring of apoptosis after ischemic stroke in TLR2-deficient mice and their TLR2-expressing counterparts. Postischemic inflammation is a significant contributor to ischemic injury development and apoptosis, and it is modified by the TLR2 receptor.
View Article and Find Full Text PDFArticle Synopsis
- The study wanted to see if a new type of MRI that looks at small bones worked as well as a regular micro-CT scan.
- They took samples from 10 patients with hip problems and compared the results from both scanning methods.
- The new MRI method was pretty close in results to the CT scan, making it a good option for checking hip bone health in the future.
Cerebral and retinal ischemia share similar pathogenesis and epidemiology, each carrying both acute and prolonged risk of the other and often co-occurring. The most used preclinical stroke models, the Koizumi and Longa middle cerebral artery occlusion (MCAO) methods, have reported retinal damage with great variability, leaving the disruption of retinal blood supply via MCAO poorly investigated, even providing conflicting assumptions on the origin of the ophthalmic artery in rodents. The aim of our study was to use longitudinal magnetic resonance assessment of cerebral and retinal vascular perfusion after the ischemic injury to clarify whether and how the Koizumi and Longa methods induce retinal ischemia and how they differ in terms of cerebral and retinal lesion evolution.
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