Should mood during intravenous alcohol administration be studied as a bi- or unipolar phenomenon? a pilot study.

In this study, alcohol was administered intravenously to study whether its effects on mood should preferably be studied as a bi- or unipolar phenomenon. This was studied in a double-blind, placebo-balanced, design on six healthy male volunteers. Of the three bipolar aspects of mood (calmness, activity, and pleasantness), only calmness was significantly affected by intravenous alcohol.

Acute tolerance during intravenous infusion of alcohol: comparison of performance during ascending and steady state concentrations--a pilot study.

Although acute tolerance (AT) to alcohol has been demonstrated in many single-dose studies, the existence of AT at steady state concentrations of alcohol has been questioned. In the present study, six subjects were examined as (1) 7.5% alcohol or (2) placebo was administered intravenously (IV).

Metabolic interaction between endogenous methanol and exogenous ethanol studied in human volunteers by analysis of breath.

Ethanol was administered to 5 healthy volunteers by intravenous infusion to maintain a constant blood-alcohol concentration (BAC) of about 0.8 mg/ml (17.4 mmol/l) for 3-4 hr.

Mechanism and regulation of ethanol elimination in humans: intermolecular hydrogen transfer and oxidoreduction in vivo.

Ethanol metabolism was studied in four healthy volunteers by intravenous infusion of a mixture of [1,1-2H2]ethanol (1.0 mmol/kg) and [2,2,2-2H3]ethanol (1.0 mmol/kg) followed by blood sampling at 10-min intervals.

Time course of breath acetaldehyde concentrations during intravenous infusions of ethanol in healthy men.

A gas chromatographic method was developed for the quantitative determination of acetaldehyde in expired alveolar air of human subjects. A rapid and direct gas-sampling system allow serial determinations and avoid the need for correcting for sample losses or poor recoveries. This method was evaluated in experiments with healthy men during different modes of intravenous infusion of ethanol.