Publications by authors named "S Sirotti"
Front Med (Lausanne)
July 2024
Article Synopsis
- - The study investigates the effectiveness of combining high molecular weight hyaluronic acid (HMWHA) and collagen tripeptide (CTP) to treat patients with both osteoarthritis (OA) and calcium pyrophosphate deposition (CPPD), conditions that worsen inflammation and cartilage damage.
- - A retrospective analysis monitored 29 patients receiving ultrasound-guided injections, measuring pain and joint function over 6 months using NRS and WOMAC scores, revealing significant improvement in both assessments.
- - Results indicated that 79% of patients experienced meaningful pain reduction (NRS) and 83% showed functional improvement (WOMAC), with the most notable benefits observed by the 6-month evaluation.
Lancet Rheumatol
November 2024
Article Synopsis
- - Calcium pyrophosphate deposition disease (CPPD) occurs when CPP crystals build up in joints, triggering inflammation and arthritis, particularly in older individuals over 60, and is linked to cartilage deterioration and osteoarthritis.
- - Common risk factors for CPPD include aging, past joint injuries, and certain metabolic conditions or genetic factors. Diagnosis relies on detecting CPP crystals in joint fluid and imaging techniques like X-rays and ultrasound.
- - Current treatment focuses on managing inflammation since there’s no cure for dissolving CPP crystals; options include prednisone for acute arthritis, low-dose colchicine, and potential use of biologics for stubborn cases.
Curr Rheumatol Rep
October 2024
Article Synopsis
- The review discusses the long-understood but poorly defined pathogenesis of calcium pyrophosphate deposition (CPPD), highlighting the need for deeper research.
- Recent advancements include the 2023 ACR/EULAR classification criteria for CPPD and new imaging techniques, although basic research is lagging behind.
- Emerging methods like Raman spectroscopy and omics sciences may pave the way for better understanding and management of CPPD as it becomes more common in an aging population.
Arthritis Rheumatol
December 2024
Article Synopsis
- The study aimed to analyze the disease, demographic, and imaging characteristics linked to different types of calcium pyrophosphate deposition (CPPD) disease, focusing on recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS).
- Researchers utilized data from an international cohort of 618 individuals to investigate the phenotypic traits of each type of CPPD and performed multivariable logistic regression to assess associations between risk factors and inflammatory phenotypes.
- Key findings indicated that longer disease duration correlated with recurrent acute arthritis, while chronic arthritis was linked to specific joint issues and less associated with metabolic risks, and CDS was more common in males with greater joint involvement. *
Radiol Clin North Am
September 2024
Article Synopsis
- The authors conducted a narrative review to highlight the latest research on ultrasound's application in major rheumatic disorders like rheumatoid arthritis, psoriatic arthritis, and crystal-induced arthropathies.
- They performed a comprehensive search on PubMed to gather articles that discuss updates on ultrasound use in these conditions.
- The review offers new definitions, criteria, and diagnostic scores, emphasizing the significance of ultrasound in enhancing patient care in rheumatic diseases.
