Publications by authors named "S Siripattanapipong"
Meloidogyne enterolobii, a guava root-knot nematode, is a highly virulent pest in tropical and subtropical regions causing galls or knots in roots of diverse plant species posing a serious threat to agriculture. Managing this nematode is challenging due to limitations in conventional identification based on isolation and microscopic classification requiring expertise and time. A colorimetric and fluorescent LAMP assay using simplified extraction method targeting rDNA-ITS region was developed to detect M.
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- Amphotericin B (AmB) is a strong antifungal and antiparasitic drug that kills leishmanial parasites by disrupting their cell membranes, making it important to study its effects on parasites like Leishmania orientalis to understand potential drug resistance.
- This study involved exposing a specific Leishmania orientalis strain to AmB and analyzing genetic changes through sequencing methods, focusing on single nucleotide polymorphisms (SNPs) and gene expression changes.
- The results indicated no significant chromosomal alterations post-treatment, but a higher incidence of SNPs in the control group, along with the downregulation of key genes, suggesting complex regulatory mechanisms might contribute to AmB resistance in this strain.
Article Synopsis
- Leishmaniasis significantly affects the health of immunocompromised individuals, especially those with HIV, in Thailand, focusing on infections caused by Leishmania martiniquensis and Leishmania orientalis.
- A study conducted in Trang Province followed 506 HIV-infected participants from 2015-2019 to investigate the incidence and persistence of Leishmania infections, utilizing tests like Direct Agglutination Test and nested PCR.
- The findings revealed a 3.2% incidence rate in initially negative participants, with older age being a key risk factor, as well as a 3.7% persistence rate in those initially positive; all individuals were asymptomatic, highlighting the need for ongoing monitoring and targeted interventions.
Development of nucleic acid lateral flow immunoassay for duplex detection of Leishmania martiniquensis and Leishmania orientalis in asymptomatic patients with HIV.
PLoS One
August 2024
Leishmaniasis, a neglected tropical disease caused by parasitic protozoa of the Leishmania genus, remains a global health concern with significant morbidity and mortality. In Thailand, the rising incidence of autochthonous leishmaniasis cases involving Leishmania (Mundinia) martiniquensis and novel Leishmania (Mundinia) orientalis underscores the critical need for accurate diagnosis and effective control strategies. This study presents a sensitive and specific nucleic acid lateral flow immunoassay (NALFIA) that integrates a duplex PCR assay with a lateral flow device (LFD) strip format.
View Article and Find Full Text PDFLeishmaniasis, a neglected tropical disease, imposes a notable health burden, especially on immunocompromised individuals such as HIV patients. Recognizing its prevalence and risk factors in specific populations is vital for effective prevention. This study in Satun Province, southern Thailand, aimed to ascertain leishmaniasis prevalence and identify associated risks among HIV-infected patients.
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