Estrogen receptors (ER) are widely expressed in the brain of many species and experimental results highlighted the role of estradiol in neuronal plasticity and behavior. Consequently, the brain is therefore a prime target for endocrine disrupting chemicals (EDCs) interacting with estrogen signaling. Very little is known about the late effects of early disruption of estrogen signaling by EDCs.
View Article and Find Full Text PDFThere is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system-disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co-operation and Development (OECD) testing framework. The current OECD approach uses different model organisms for different endocrine modalities, leading to a high number of animal tests.
View Article and Find Full Text PDFPathways underlying neurodevelopmental effects of endocrine disruptors (EDs) remain poorly known. Expression of brain aromatase (aroB), responsible for estrogen production in the brain of teleosts, is regulated by estrogenic EDs and could play a role in their behavioral effects. We exposed zebrafish eleutheroembryos (0-120 h post-fertilization) to various concentrations of 16 estrogenic chemicals (incl.
View Article and Find Full Text PDFA cross-sectional study was carried out in the Sidama region's Hawassa town from March 2021 to July 2021 with the aim of estimating the prevalence and associated factors of dog gastrointestinal helminths. A total of 384 dogs were randomly selected, and their feces were examined using a flotation technique. For data analysis, descriptive statistics and chi-square analyses were employed, and a -value of less than 0.
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