Clinical performance of a low cost near infrared sensor for continuous glucose monitoring applied with subcutaneous microdialysis.

In this work we present a low cost, minimally invasive, and chip-based near infrared (NIR) sensor, combined with subcutaneous microdialysis, for continuous glucose monitoring (CGM). The sensor principle is based on difference absorption spectroscopy in the 1st overtone band known to be dominated by glucose-specific absorption features. The device comprises a multi-emitter LED and InGaAs-photodiodes, which are located on a single electronic board (non-disposable part), connected to a personal computer via Bluetooth.

In vivo evaluation of a chip based near infrared sensor for continuous glucose monitoring.

In this paper we describe the concept and in vivo results of a minimally invasive, chip-based near infrared (NIR) sensor, combined with microdialysis, for continuous glucose monitoring. The sensor principle is based on difference absorption spectroscopy in selected wavelength bands of the near infrared spectrum (1300 nm, 1450 nm, and 1550 nm) in the 1st overtone band. In vitro measurements revealed a linear relationship between glucose concentration and the integrated difference spectroscopy signal with a coefficient of determination of 99% in the concentration range of 0-400mg/dl.