Publications by authors named "S Sigal"

Arrhythmias are a hallmark of myocardial infarction (MI) and increase patient mortality. How insult to the cardiac conduction system causes arrhythmias following MI is poorly understood. Here, we demonstrate conduction system restoration during neonatal mouse heart regeneration versus pathological remodeling at non-regenerative stages.

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Objectives: Hepatitis B virus (HBV) is endemic in West Africa. Because of immigration to the United States, screening and transition to long-term care is a significant public health concern. We describe the challenges of integrating individuals identified in a screening program into long-term care and the spectrum of disease severity.

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Background: Hepatitis B (HBV) and hypertension (HTN) are prevalent in West Africa (WA). Inadequate control is common, and evaluation and management are challenging among immigrants due to unfamiliarity with the United States (US) healthcare system. While HBV is stigmatised, HTN is recognised as an important condition.

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Article Synopsis
  • Frailty is recognized as a critical factor affecting health outcomes in elderly patients, and this study utilized Bayesian statistics to better understand its effects compared to traditional frequentist methods.
  • Analysis of data from over 10,000 older patients showed a 30-day all-cause mortality rate of 43%, revealing that frail patients had a significantly higher mortality rate (51%) than non-frail patients (38%).
  • The findings indicate that frailty is consistently linked to worse outcomes, highlighting its importance in patient care, particularly when assessed as a continuous variable on the Clinical Frailty Scale, which can help tailor treatment for this vulnerable demographic.
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