Depression-inducing and antidepressive effects of neuroleptics. Experiences with flupenthixol and flupenthixol decanoate.

The antidepressive and anxiolytic efficacy of flupenthixol has been investigated in numerous controlled and open trials involving patients with endogenous, reactive as well as senile depressions. When administered at a mean daily single or multiple dose of 1-2 mg, flupenthixol proved to be a very effective and well-tolerated antidepressant. As opposed to some of the currently available antidepressants, flupenthixol has a rapid onset of action which is often displayed within the first 2-3 days following its application.

[cis(Z)-Clopenthixol decanoate--a new depot neuroleptic].

cis(Z)-Clopenthixol decanoate is a new depot neuroleptic that belongs to the group of thioxanthenes. It has a duration of effect ranging from 2 to 4 weeks and it is used for long-term therapy of chronic schizophrenic patients. The aim of this review is to represent the chemistry, pharmacology, pharmacokinetics, dosage and efficacy of this drug.

[Therapeutic experiences with clotiazepam (Trecalmo), a new anxiolytic drug from the thienodiazepine group. Results of a field study on 186 patients].

The efficacy and the compatibility of the new anxiolytic Trecalmo (Clotiazepam) were investigated by means of a field trial covering 186 patients, suffering from anxiety and tension as well as from psychosomatic disorders. The new drug proved to be remarkably effective in symptoms as anxiety, restlessness, irritations, tension headache as well as functional cardiovascular diseases and digestive disorders. The compatibility was good.

[Studies on the long acting neuroleptic agent flupenthixol decanoate--a review (author's transl)].

The development of long acting neuroleptic agents is considered as important progress in the treatment of schizophrenic psychoses. An outline of pharmacological and clinical results with flupenthixol decanoate is given. Special attention is paid to pharmacokinetics, the methods for determining plasma concentration, to the profile of action and duration of action, to other dosage as well as to safety.