Publications by authors named "S Siboni"
Introduction: High-resolution manometry (HRM) allows assessment of esophagogastric junction (EGJ) disruption. While type 3 EGJ predicts definitive gastroesophageal reflux disease (GERD), type 2 EGJ is less clearly implicated in GERD pathogenesis. This study aimed to characterize physiologic findings in type 2 EGJ to determine if the HRM-based Milan Score can define GERD within type 2 EGJ.
View Article and Find Full Text PDFType 3 von Willebrand disease (VWD), the most severe form of VWD, is an inherited recessive bleeding disorder caused by the complete deficiency of von Willebrand factor (VWF). The reported prevalence is 1 per million but varies worldwide according to the frequency of consanguineous marriages. The clinical phenotype is characterized not only by mucocutaneous bleedings, but also by hemarthroses and muscle hematoma, as in patients with moderate hemophilia.
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- Early diagnosis of joint damage in haemophilia is crucial to prevent further complications and enhance patient management, with the HJHS and HEAD-US scores being primary evaluation tools.
- This study aims to compare the effectiveness of HJHS and HEAD-US scores by two independent experts to assess joint health in patients with haemophilia.
- Results show a strong correlation between the two methods, particularly highlighting the ultrasound's ability to detect mild synovitis even when physical examination shows no swelling, underscoring the importance of using both assessments in clinical practice.