20 µm resolution multipixel ghost imaging with high-energy x-rays.

Hard x-ray imaging is indispensable across diverse fields owing to its high penetrability. However, the resolution of traditional x-ray imaging modalities, such as computed tomography (CT) systems, is constrained by factors including beam properties, the limitations of optical components, and detection resolution. As a result, the typical resolution in commercial imaging systems that provide full-field imaging is limited to a few hundred microns, and scanning CT systems are too slow for many applications.

Synchrotron-based x ray fluorescence ghost imaging.

X ray fluorescence ghost imaging (XRF-GI) was recently demonstrated for x ray lab sources. It has the potential to reduce the acquisition time and deposited dose by choosing their trade-off with a spatial resolution while alleviating the focusing constraints of the probing beam. Here, we demonstrate the realization of synchrotron-based XRF-GI: we present both an adapted experimental setup and its corresponding required computational technique to process the data.

Targeting tumor-associated MUC1 overcomes anoikis-resistance in pancreatic cancer.

The third leading cause of cancer-related deaths in the United States is pancreatic cancer, more than 95% of which is pancreatic ductal adenocarcinoma (PDA). The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25% are eligible. Tumor recurrence and metastasis are the main causes of cancer-related mortality.

Overexpression of MUC1 Induces Non-Canonical TGF-β Signaling in Pancreatic Ductal Adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. Transforming Growth Factor Beta (TGF-β) is a cytokine that switches from a tumor-suppressor at early stages to a tumor promoter in the late stages of tumor development, by yet unknown mechanisms. Tumor associated MUC1 is aberrantly glycosylated and overexpressed in >80% of PDAs and is associated with poor prognosis.

Efficient Interaction of Heralded X-Ray Photons with a Beam Splitter.

We report the experimental demonstration of efficient interaction of multi-kilo-electron-volt heralded x-ray photons with a beam splitter. The measured heralded photon rate at the outputs of the beam splitter is about 0.01  counts/s which is comparable to the rate in the absence of the beam splitter.