CD4 and CD8 T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment.

SARS-CoV-2 infection induces the generation of virus-specific CD4 and CD8 effector and memory T cells. However, the contribution of T cells in controlling SARS-CoV-2 during infection is not well understood. Following infection of C57BL/6 mice, SARS-CoV-2-specific CD4 and CD8 T cells are recruited to the respiratory tract, and a vast proportion secrete the cytotoxic molecule granzyme B.

A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection.

Most neutralizing anti-SARS-CoV-2 monoclonal antibodies (mAbs) target the receptor binding domain (RBD) of the spike (S) protein. Here, we characterize a panel of mAbs targeting the N-terminal domain (NTD) or other non-RBD epitopes of S. A subset of NTD mAbs inhibits SARS-CoV-2 entry at a post-attachment step and avidly binds the surface of infected cells.

Extraction of iron from laterite soil and green synthesis of laterite nano iron catalyst (GLaNICs) for its application as Fenton's catalyst in the degradation of triclosan.

Laterite based nano iron particles were synthesized using natural laterite extract as a precursor and Psidium guajava plant extract for its application as Fenton's catalyst in the degradation of triclosan. Chemical digestion method was used for the extraction of iron from laterite soil. Synthesized nano iron catalyst was characterized using SEM-EDS, XRD and FTIR and evaluated for its catalytic application in the Fenton's oxidation of triclosan.

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains.

Although mRNA vaccines encoding the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevent COVID-19, the emergence of new viral variants jeopardizes their efficacy. Here, we assessed the immunogenicity and protective activity of historical (mRNA-1273, designed for Wuhan-1 spike protein) or modified (mRNA-1273.351, designed for B.