3-Hydroxy coumarin demonstrates anti-biofilm and anti-hyphal efficacy against Candida albicans via inhibition of cell-adhesion, morphogenesis, and virulent genes regulation.

Candida albicans, a common fungus of human flora, can become an opportunistic pathogen and causes invasive candidiasis in immunocompromised individuals. Biofilm formation is the prime cause of antibiotic resistance during C. albicans infections and treating biofilm-forming cells is challenging due to their intractable and persistent nature.

Region of interest (ROI) selection using vision transformer for automatic analysis using whole slide images.

Selecting regions of interest (ROI) is a common step in medical image analysis across all imaging modalities. An ROI is a subset of an image appropriate for the intended analysis and identified manually by experts. In modern pathology, the analysis involves processing multidimensional and high resolution whole slide image (WSI) tiles automatically with an overwhelming quantity of structural and functional information.

Differentially expressed transcripts of Tetracapsuloides bryosalmonae (Cnidaria) between carrier and dead-end hosts involved in key biological processes: novel insights from a coupled approach of FACS and RNA sequencing.

Tetracapsuloides bryosalmonae is a malacosporean endoparasite that infects a wide range of salmonids and causes proliferative kidney disease (PKD). Brown trout serves as a carrier host whereas rainbow trout represents a dead-end host. We thus asked if the parasite adapts to the different hosts by changing molecular mechanisms.

Many-Body Quantum Chaos and Emergence of Ginibre Ensemble.

We show that non-Hermitian Ginibre random matrix behaviors emerge in spatially extended many-body quantum chaotic systems in the space direction, just as Hermitian random matrix behaviors emerge in chaotic systems in the time direction. Starting with translational invariant models, which can be associated with dual transfer matrices with complex-valued spectra, we show that the linear ramp of the spectral form factor necessitates that the dual spectra have nontrivial correlations, which in fact fall under the universality class of the Ginibre ensemble, demonstrated by computing the level spacing distribution and the dissipative spectral form factor. As a result of this connection, the exact spectral form factor for the Ginibre ensemble can be used to universally describe the spectral form factor for translational invariant many-body quantum chaotic systems in the scaling limit where t and L are large, while the ratio between L and L_{Th}, the many-body Thouless length is fixed.

Vaccine stockpile sharing for selfish objectives.

The COVAX program aims to provide global equitable access to life-saving vaccines. Despite calls for increased sharing, vaccine protectionism has limited progress towards vaccine sharing goals. For example, as of April 2022 only ~20% of the population in Africa had received at least one COVID-19 vaccine dose.