Publications by authors named "S Shiva"
The association of dietary approaches to stop hypertension measured by the food frequency questionnaire with metabolic syndrome and some inflammatory biomarkers in adolescents with obesity: a case-control study.
J Health Popul Nutr
January 2025
Background: Globally, obesity trends are a serious public health concern. Adolescent obesity is associated with cardiometabolic risk and metabolic disorders in adolescence and may persist into adulthood. The current study was designed to explore the Dietary Approaches to Stop Hypertension (DASH) in adolescents and its relationship with obesity, insulin resistance, metabolic syndrome (MetS), and some inflammatory biomarkers.
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- Recent findings highlight the importance of communication between lysosomes and mitochondria in regulating tumor growth, particularly in squamous cell carcinomas (SCCHN) with high TMEM16A expression.
- About 30% of SCCHN cases overexpress TMEM16A, leading to increased mitochondrial content and reliance on mitochondrial complex I for cancer cell survival.
- Targeting the interaction between lysosomal and mitochondrial functions may offer new therapeutic strategies for improving outcomes in patients with SCCHN.
Article Synopsis
- - Alzheimer's Disease (AD) and related dementias are becoming a major worldwide issue due to the aging population, characterized by damage to neurological tissue and the presence of amyloid plaques and neurofibrillary tangles.
- - Recent research has focused on the role of reactive oxygen species (ROS), particularly the NADPH Oxidase 2 (NOX2) protein, which is linked to inflammation and vascular processes in the brain and plays a key role in AD development.
- - This review highlights the latest findings on how NOX2 contributes to the progression of AD and discusses promising therapies targeting NOX2 for managing and treating the disease.
Suppression or overexpression of transmembrane proteins of the Wnt family and receptor tyrosine kinases (ROR1 and ROR2) is implicated in the causation of cancer. The objective of this study was to determine the expression of ROR2 in patients with giant cell tumor of bone (GCT) by quantitative PCR (qPCR). In this case‒control study, samples of tumor tissue (patients) and bone from the tumor-free margin (controls) were subjected to qPCR in patients who underwent definitive treatment.
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- Reproductive status significantly affects metabolism and health throughout an organism's lifespan, with mitochondrial function being a key mediator in this relationship.
- Research using a germline ablation model showed that loss of germline stem cells (GSC) decreases mitochondrial volume and respiratory function in young adults, yet helps preserve mitochondrial activity as organisms age and when facing cold stress, leading to better survival rates.
- The study identified that the transcription factor NHR-49/PPARα is crucial for maintaining mitochondrial health and cold stress resistance, highlighting the complex interplay between reproductive signals and overall health.