Publications by authors named "S Shindo"
Article Synopsis
- The study investigated the effect of administering P2Y inhibitors during endovascular treatment (EVT) in patients with anterior circulation thrombosis due to acute ischemic stroke.
- Out of 242 patients analyzed, those who received P2Y inhibitors had a significantly higher rate of carotid artery stenting and better functional outcomes after 90 days compared to those who did not.
- The results showed that patients treated with P2Y inhibitors had an adjusted odds ratio of 6.65 for better outcomes, suggesting a strong positive association with the use of these medications.
Background: Clinical data on patients infected with influenza B Victoria (BV) after the approval of baloxavir is lacking.
Methods: This observational study of the Japanese 2023-2024 influenza season analyzed data from 25 outpatients with A(H1N1)pdm09, 36 with A(H3N2), and 65 with BV. Viral samples were collected before and after administering an antiviral (70 patients received baloxavir and 56 received a neuraminidase inhibitor), on days 1, 5, and 10.
Study Design: Retrospective cohort study.
Objective: To investigate the incidence of and risk factors for segmental motor paralysis after anterior cervical spine surgery.
Summary Of Background Data: Segmental motor paralysis is a potential complication following both anterior and posterior cervical decompression procedures; however, previous studies investigating risk factors for segmental motor paralysis after anterior cervical spine surgery were limited by small sample sizes.
Unlabelled: Mechanical stimulus to the multicellular bone unit (MBU) plays a key role in normal bone remodeling, whereas disuse osteoporosis, for example, represents loss of bone owing to lack of mechanical stresses. The analogy can be applied to a variety of pathogenic bone lytic complications, including periodontitis, in which local mechanical stress appears to be diminished. The activation of mechanosensitive Piezo1 Ca channel expressed by osteoblasts and osteocytes in the MBU elicits the osteogenic signals in those cells.
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- - Fluoride ingestion during tooth development can lead to dental fluorosis, and it activates histone acetyltransferase (HAT), which modifies the protein p53 and contributes to fluoride toxicity in specific mouse cells (LS8).
- - The study showed that fluoride modifies histone acetylation, altering gene expression in LS8 cells, as evidenced by increased acetylation levels of certain genes and corresponding mRNA expression when treated with fluoride.
- - This research is the first to highlight that fluoride treatment can lead to epigenetic changes through H3 acetylation, indicating a need for further investigation into how fluoride affects enamel development on a genetic level.