Investigation of bidirectional causal association between temporomandibular disorders and five mental disorders.

Objective: This study utilized two-sample Mendelian randomization (TSMR) to investigate the bidirectional causal associations between temporomandibular disorders (TMD) and five mental disorders.

Methods: Single-nucleotide polymorphisms (SNPs) linked to TMD were extracted from the Genome-Wide Association Studies (GWAS) database. The SNPs selected as instrumental variables (IVs) were required to have strong associations with the exposure phenotype and to meet the assumptions of Mendelian randomization (MR) analysis.

Transcriptional signatures of secondary hair follicles during annual cashmere growth.

Cashmere grows from the secondary hair follicles (SHFs) that synchronously regenerate and degenerate in a circannual rhythm. Most studies examining factors related to cashmere growth have been performed on goat skin. However, the molecular properties and regulators preferentially expressed in SHFs are less clear.

An Artificial Intelligence-driven Revolution in Orthopedic Surgery and Sports Medicine.

With the advancement of population aging, the incidence of orthopedic diseases increases annually. The early diagnosis and precise treatment of many orthopedic diseases still require advancements in technology to address effectively. With the rapid development of artificial intelligence (AI), this technology is expected to achieve early diagnosis and improved treatment of many diseases, providing revolutionary changes in clinical.

Association between hemoglobin and in-hospital mortality in critically ill patients with sepsis: evidence from two large databases.

Background: The relationship between baseline hemoglobin levels and in-hospital mortality in septic patients remains unclear. This study aimed to clarify this association in critically ill patients with sepsis.

Methods: Patients with sepsis were retrospectively identified from the Medical Information Mart for Intensive Care-IV (MIMIC-IV 2.

Genome-wide characterization of Solanum tuberosum UGT gene family and functional analysis of StUGT178 in salt tolerance.

UDP-glycosyltransferases (UGTs) widely exist in plants and play essential roles in catalyzing the glycosylation reaction associated with metabolic processes. UGT gene family has been identified in many species to date. However, the comprehensive identification and systematic analysis have not been documented yet in the latest potato genome.