¿Está disponible en español? A Systematic Review of Preventive Parenting Interventions Delivered in a Language Other Than English in the United States.

Decades of research have demonstrated that parenting programs are effective at changing parent behaviors and subsequently preventing myriad child outcomes including anxiety, depression, substance use, and HIV infection. However, most research into preventive parenting interventions in the United States has been conducted with English-speaking populations only. There is a clear mismatch between the linguistic diversity of the United States and the available evidence for preventive parenting programs.

A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice.

Accumulation of senescent cells (SnCs) plays a causative role in many age-related diseases and has also been implicated in the pathogenesis and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Senolytics that can selectively kill SnCs have the potential to be developed as therapeutics for these diseases. Here we report the finding that 753b, a dual BCL-xL/BCL-2 proteolysis-targeting chimera (PROTAC), acts as a potent and liver-tropic senolytic.

Knowledge, Attitude, and Practice in Dental Trauma Management Among Schoolteachers in Taif, Saudi Arabia.

In Saudi Arabia, dental trauma is regarded as one of the most important issues affecting schoolchildren. This study evaluated Saudi Arabian schoolteachers' knowledge, attitude, and practice regarding emergency dental trauma management. A cross-sectional study was conducted on 263 schoolteachers from 25 schools; 50.

Enhancing engagement in parenting programs: A comparative study of in-person, online, and telehealth formats.

Introduction: Parenting programs are widely used to prevent and ameliorate children's emotional and behavioral problems but low levels of engagement undermine intervention effectiveness and reach within and beyond research settings. Technology can provide flexible and cost-effective alternate service-delivery formats for parenting programs, and studies are needed to assess the extent to which parents are willing to engage with digitally assisted formats.

Methods: After Deployment, Adaptive Parenting Tools (ADAPT) is an evidence-based parenting program for military families.