Publications by authors named "S Sharath"
Introduction: Methotrexate (MTX) acts by suppressing multiple immune pathways involved in the pathogenesis of lichen planus (LP). Trials assessing the efficacy and relapse rates of methotrexate in LP are lacking.
Objectives: Our objective was to analyze the efficacy and safety of low-dose methotrexate in generalized and recalcitrant LP patients retrospectively and to assess the relapse rates in patients after stopping MTX therapy.
There are no standard guidelines on the management of Conidiobolus infections, and many antifungals have been used, either alone or in combination. Relapses are common even after successful management. Although localized, they can result in severe facial disfigurement and may rarely cause disseminated entomophthoromycosis, which can have fatal complications.
View Article and Find Full Text PDFThere are conflicting reports regarding the roles of T helper-17 (Th17) and T regulatory (Treg) cells in type 1 leprosy reactions (T1Rs). Also, literature on the correlation of immunological parameters with a validated scoring system and the effect of treatment on cytokines is lacking. Adult patients with untreated T1R and nonreactional spectrum-matched controls were included in the study for comparison of levels of Th17 and Treg pathway cytokines in serum, skin lesions (reactional), and peripheral blood mononuclear cells (PBMCs) culture supernatants.
View Article and Find Full Text PDFArticle Synopsis
- * A study analyzed tissue samples from 11 patients with difficult-to-treat CHE, finding increased levels of key cytokines (IL-4, TNF-α, IFN-γ) compared to unaffected skin.
- * Tofacitinib was administered to 15 patients, showing promising results with a mean improvement in eczema severity after 4 weeks, although some experienced side effects and relapses after stopping treatment.