Publications by authors named "S Shanker"
Many viral proteins form biomolecular condensates via liquid-liquid phase separation (LLPS) to support viral replication and evade host antiviral responses, and thus, they are potential targets for designing antivirals. In the case of nonenveloped positive-sense RNA viruses, forming such condensates for viral replication is unclear and less understood. Human noroviruses (HuNoVs) are positive-sense RNA viruses that cause epidemic and sporadic gastroenteritis worldwide.
View Article and Find Full Text PDFDe novo normal karyotype AML 2017ELN and 2022ELN Genetic Risk Category Changes and Overall Survival in Induction Treated Patients.
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- * The study found that CRS boosts TPH2 expression and activity specifically in the left adrenal gland while decreasing TPH levels in the dorsal raphe nucleus (DRN), which is involved in serotonin production.
- * Overall, the results suggest that CRS leads to higher serotonin synthesis in the adrenal glands due to increased TPH2, highlighting a complex interaction between stress and hormone regulation in the body.
Article Synopsis
- Some viruses make special clusters called condensates to help them copy their genetic material and escape the body’s defenses against them.
- Human noroviruses, which cause stomach sickness, use a part called RNA-dependent-RNA polymerase (RdRp) to form these condensates to aid in their replication.
- Researchers found that these condensates are important for virus replication, allowing the virus to avoid interfering with other processes in the infected cells.