Publications by authors named "S Shakya"

Introduction: Intranasal steroids are effective in managing adenoid hypertrophy in children, but the evidence regarding technique of use for optimal results is lacking.

Methods: CFD analysis, with discrete phase modelling was done to simulate nasal spray in nasal cavity and drug delivery in the region of adenoids. The findings were validated using a 3D model designed from CT scan of the same region.

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Objective: Head and trunk control is essential for enhancing engagement and participation by improving visual integration, respiration, oromotor skill, arm control, and self-care. Our study protocol aims to investigate the effect of novel Head And Trunk Control Rehabilitation (HATCoRe) device on promoting head and trunk control in children with Cerebral Palsy (CP).

Method: This single subject multiple baseline design trial will include six children with CP aged two to 10 years, exhibiting delayed head and trunk control, having Gross Motor Function Classification System level IV and V will be enrolled.

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Introduction: Cancer is the primary cause of death globally, and despite the significant advancements in treatment and survival rates, it is still stigmatized in many parts of the world. However, there is limited public health research on cancer stigma among the general female population in Nepal. Therefore, this study aims to determine the prevalence of cancer stigma and its associated factors in this group.

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Introduction: Tuberculosis is a major public health issue in developing countries. Vasculitis, resulting from tubercular meningitis, can lead to stroke.

Case Presentation: A 33-year-old male presented to the Emergency Department with relapsing-remitting fever with an evening rise in temperature for 1 month, personality changes (aggression and mutism) for 2 weeks, followed by difficulty in moving his lower limbs, and bowel and bladder incontinence.

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Article Synopsis
  • Recent advancements in non-invasive drug administration methods are focused on alternatives to traditional needle injections, with transdermal drug delivery systems (TDDS) being the most promising option due to their low rejection rates and patient comfort.
  • * TDDS has applications in both the pharmaceutical and skincare industries, allowing for targeted local drug delivery and reducing unwanted drug distribution.
  • * Transferosomes have emerged as effective carriers for various therapies, helping to overcome the challenges of delivering larger and hydrophilic molecules through the skin by taking advantage of hydration gradients for better absorption.*
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