Publications by authors named "S Sfregola"
Article Synopsis
- Uterine lipoleiomyosarcomas (L-LMS) and liposarcomas (LPS) are very rare malignant tumors occurring in the uterus, particularly affecting postmenopausal women, with common symptoms being metrorrhagia and abdominal pain.
- The case discussed involves a patient with L-LMS and pleomorphic LPS, with contrast-enhanced computed tomography (CECT) playing a critical role in diagnosis by distinguishing between the tumor components.
- The essay aims to highlight the importance of CECT imaging in diagnosing these rare tumors and includes a review of existing literature on liposarcomas in the uterine corpus.
Over the past decade, dupilumab, a monoclonal human antibody that inhibits interleukin (IL)-4 and IL-13 signalling, has revolutionized the therapeutic management of moderate-to-severe atopic dermatitis (AD), facilitating long-term control of its signs and symptoms. The aim of this study was to identify histological predictors of the efficacy of dupilumab after 16 weeks of treatment in a cohort of 40 adults with moderate-to-severe AD who had undergone a skin biopsy for diagnostic purposes before treatment initiation. We found that Eczema Area and Severity Index (EASI) 75 and EASI 90 responses at week 16 were significantly associated with perivascular localization [odds ratio (OR) 17.
View Article and Find Full Text PDFMorphological and immunohistochemical evaluation in distinguishing post-radiotherapy serous-like endometrial change (PoRSEC) and serous endometrial intraepithelial carcinoma (SEIC).
Damiano Arciuolo Giulia Scaglione Antonio Travaglino Nicoletta D'Alessandris Angela Santoro Stefania Sfregola
Virchows Arch
December 2024
Article Synopsis
- * Out of 244 patients reviewed, 36 (14.7%) exhibited post-radiotherapy serous-like endometrial changes (PoRSEC), showing similarities in nuclear atypia with SEIC but differing in specific features like papillary architecture and mitotic activity.
- * Immunohistochemical findings revealed that while SEIC consistently showed aberrant p53 expression and high Ki67 levels, PoRSEC was more variable and included some p53 positivity, making differential diagnosis challenging but with distinct patterns between the two.
Article Synopsis
- Acquired reactive perforating collagenosis is a rare skin disorder where abnormal connective tissue pushes through the skin, often linked to systemic diseases like diabetes and chronic kidney disease, or inflammatory skin conditions like atopic dermatitis.
- The case study focuses on a 35-year-old man who had this condition along with atopic dermatitis and did not respond to typical treatments but achieved complete relief after 12 weeks of dupilumab therapy.
- Dupilumab, which targets specific cytokines involved in skin inflammation and itching, proved effective in treating both atopic dermatitis and the associated reactive perforating collagenosis in this patient, suggesting it could be a viable treatment option for others with similar conditions.
Article Synopsis
- * Immunohistochemistry for MMR (mismatch repair) proteins like MLH1, MSH2, MSH6, and PMS2 is the preferred method globally to diagnose MSI in tumors.
- * This review focuses on providing updated knowledge about MMR deficiency and MSI in endometrial cancer, highlighting the assessment, common interpretation issues, and the reporting of MMR status.