A New Sperm Concentration Threshold for Y Chromosome Microdeletion Analysis in Infertile Men: Could It Be Azoopermia?

Objective: We aimed to assess the frequency of Y-chromosome microdeletions (YCMs) in a non-multiethnic urban population in our region, define predictive factors, and determine a new clinical threshold for YCMs in infertile men.

Materials And Methods: A total of 281 patients with a sperm concentration ≤5 million/mL were retrospectively evaluated. Oligozoospermic and/or azoospermic patients with a sperm concentration of ≤5 million/mL were screened for the YCM analysis.

What do medical faculty students think about telehealth?

Objective: We aimed to evaluate medical school students' knowledge and approaches regarding telehealth.

Method: In this descriptive study, an electronic survey was conducted among students attending the Faculties of Medicine at Health Sciences University. The first part of the Form included questions evaluating individual characteristics and telehealth approaches, and the second part included opinions and suggestions regarding telehealth usage topics.

What are the determinants of change in walking fitness in patients with a history of depression following cardiac rehabilitation?

Aims: This study aims to investigate the demographic, clinical, and service-level factors determining change in walking fitness in cardiac rehabilitation (CR) patients with a history of depression following the CR programme.

Methods And Results: The National Audit of Cardiac Rehabilitation clinical data were used to identify 1476 patients with a history of depression who had their pre- and post-incremental shuttle walk test (ISWT) recorded between 1 January 2016 and 31 January 2020. A multiple linear regression was conducted to examine the determinants of change in walking fitness (m) following CR.

Recessive variants in the intergenic locus cause monogenic kidney disease responsive to anti-proteinuric treatment.

In genetic disease, an accurate expression landscape of disease genes and faithful animal models will enable precise genetic diagnoses and therapeutic discoveries, respectively. We previously discovered that variants in , encoding nitric oxide synthase 1 (NOS1) adaptor protein, cause monogenic nephrotic syndrome (NS). Here, we determined that an intergenic splice product of N / and neighboring , which precludes NOS1 binding, is the predominant isoform in mammalian kidney transcriptional and proteomic data.