Publications by authors named "S Senthuran"
Objective: The optimal timing of vasopressin initiation as an adjunctive vasopressor remains unclear. We aimed to study the association between the timing of vasopressin commencement, pre-specified physiological parameters, and hospital mortality.
Design: We conducted a multicentre, retrospective, observational study.
Objective: Knowledge of intensive care unit (ICU) acquired hypernatremia (ICU-AH) has been hampered by the absence of granular data and confounded by variable definitions and inclusion criteria.
Design: Multicentre retrospective cohort study.
Setting: Twelve ICUs in Queensland (QLD), Australia.
Article Synopsis
- Critically ill patients with bloodstream infections (BSIs) who experience hypothermia are at a higher risk of death, but the impact of rewarming rates on their outcomes is not well understood.
- In a study involving 3951 ICU admissions, researchers found that 8.4% of hypothermic patients had temperatures below 34.9°C, and lower temperatures were linked to higher severity of illness and a greater need for organ support.
- The 90-day case-fatality rate was 22.9% overall, with significantly higher rates among those with lower temperatures; faster rewarming was associated with lower mortality rates even after accounting for illness severity and comorbidities.
Purpose: Clinical trials focusing on critically ill patients with metabolic acidosis, a common exclusion criterion is the presence of a PaCO > 45 mmHg. The aim of this study was to assess the impact of mild hypercapnia on patient characteristics, severity, and clinical outcomes in critically ill patients with metabolic acidosis.
Material And Methods: Multicentre, retrospective, observational study conducted in 12 intensive care units (ICUs) in Queensland, Australia.
Article Synopsis
- Doctors studied how hydrocortisone, a medicine, is used for patients with septic shock in 12 hospitals to see if its use changed after a big research trial called the ADRENAL trial.
- They found that more patients started getting hydrocortisone after the trial was published, showing an increase from 28% to 43% over time.
- The study showed that the change in how often hydrocortisone was given was significant during two different time periods: right after the trial was published and the transition period before that.