Molecular cloning of a mutated HOXB7 cDNA encoding a truncated transactivating homeodomain-containing protein.

Homeodomain-containing proteins regulate, as transcription factors, the coordinated expression of genes involved in development, differentiation, and malignant transformation. We report here the molecular cloning of a mutated HOXB7 transcript encoding a truncated homeodomain-containing protein in MCF7 cells. This is a new example of mutation affecting the coding region of a HOX gene.

Multiple mRNA species are generated by alternate polyadenylation from the human calmodulin-I gene.

Three distinct genes encode an identical calmodulin protein in mammalian cells. In addition, multiple mRNA transcripts, with approximate sizes of 1.6 kb and 4.