Publications by authors named "S Sears"

Importance: Evidence regarding the effect of pudendal nerve blockade during vaginal surgery is conflicting. Previous studies compared pudendal nerve blockade to either normal saline placebo injection or no injection, demonstrating small or no difference in pain outcomes. Studies investigating nerve blocks at the time of vaginal surgery have not evaluated the effect of infiltration of the space around the pudendal nerve.

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The Trier Social Stress Test (TSST) is a strategy for inducing acute psychological stress and increases in glucocorticoid levels. Here we describe the methodology and implementation of a Semi-Virtual Trier Social Stress Test (SV-TSST) which combines the control of a laboratory environment with reduced need for in-person logistical support and enhanced social distancing without the need for specialized equipment. During the SV-TSST, the participant is guided through the baseline, anticipatory, challenge, and recovery phases of the test by an in-person experimenter.

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Article Synopsis
  • A new machine learning algorithm was developed to predict all-cause mortality and heart failure hospitalization in patients with implantable cardioverter-defibrillators (ICDs), aiming to improve personalized risk assessments compared to traditional methods.
  • The study used a large cohort from the Veterans Health Administration, analyzing data to identify risk factors and utilizing random forest techniques for accurate predictions over 3-month and 1-year intervals.
  • Results showed strong predictive accuracy, with receiver-operating characteristic curve values indicating the model's effectiveness in distinguishing patient outcomes based on baseline demographics and ICD data.
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