Diabetic Macular Oedema - Patient Characteristics and the Reality of Treatment in a German University Hospital.

Background: Diabetic macular oedema (DME) is associated with significant loss of visual acuity. Intravitreal VEGF inhibitor injection is the gold standard in treating this disease; second-line treatment consists of intravitreal steroid injections. This treatment has already undergone extensive investigation in large randomised controlled trials.

Distribution and diversity of classical deacylases in bacteria.

Classical Zn-dependent deac(et)ylases play fundamental regulatory roles in life and are well characterized in eukaryotes regarding their structures, substrates and physiological roles. In bacteria, however, classical deacylases are less well understood. We construct a Generalized Profile (GP) and identify thousands of uncharacterized classical deacylases in bacteria, which are grouped into five clusters.

Identifications of Similarity Metrics for Patients With Cancer: Protocol for a Scoping Review.

Background: Understanding the similarities of patients with cancer is essential to advancing personalized medicine, improving patient outcomes, and developing more effective and individualized treatments. It enables researchers to discover important patterns, biomarkers, and treatment strategies that can have a significant impact on cancer research and oncology. In addition, the identification of previously successfully treated patients supports oncologists in making treatment decisions for a new patient who is clinically or molecularly similar to the previous patient.

Binary progenitor systems for Type Ic supernovae.

Core-collapse supernovae are explosions of massive stars at the end of their evolution. They are responsible for metal production and for halting star formation, having a significant impact on galaxy evolution. The details of these processes depend on the nature of supernova progenitors, but it is unclear if Type Ic supernovae (without hydrogen or helium lines in their spectra) originate from core-collapses of very massive stars (>30 M) or from less massive stars in binary systems.

[Psychosocial stress and working conditions of nursing home staff in Covid-19 pandemic: A cross-sectional study].

Psychosocial stress and working conditions of nursing home staff in Covid-19 pandemic: A cross-sectional study With the onset of the Covid-19 pandemic in March 2020 there were numerous changes in the daily professional lives of healthcare professionals. Since the focus has been mainly on hospital staff so far, it is also important to watch the care situation in old people's and nursing homes. This study aimed to investigate the impact of the Covid-19 pandemic on the daily professional life, the psychosocial situation and the interpersonal relationships of nursing staff in old people's and nursing homes in Brandenburg.