Publications by authors named "S Schuh-Hofer"
Article Synopsis
- - The term "nociplastic pain" describes pain that arises from a sensitized nociceptive system, yet cannot be classified as nociceptive or neuropathic, leading researchers to evaluate a new grading system for distinguishing chronic pain types.
- - The study involved 81 patients with conditions like fibromyalgia, complex regional pain syndrome, osteoarthritis, and peripheral nerve injury, using various methods to classify their pain as nociplastic; results showed that most chronic primary pain was widespread and not due to clear nociceptive or neuropathic mechanisms.
- - Despite the grading system having good specificity (93%) when identifying pain types, its sensitivity was low (60%) and inadequate for screening, indicating a need for improvements,
Background: Clinical trials have shown that cenobamate (CNB) is an efficacious and safe anti-seizure medication (ASM) for drug-resistant focal epilepsy. Here, we analyzed one of the largest real-world cohorts, covering the entire spectrum of epilepsy syndromes, the efficacy and safety of CNB, and resulting changes in concomitant ASMs.
Methods: We conducted a retrospective observational study investigating CNB usage in two German tertiary referral centers between October 2020 and June 2023 with follow-up data up to 27 months of treatment.
Article Synopsis
- The study investigates how different stages of sleep, particularly REM sleep, affect neural activity and memory consolidation in both rodents and humans.
- It highlights the importance of non-oscillatory brain activity during REM sleep, suggesting that it helps recalibrate neural networks.
- The extent of this recalibration during REM is linked to better overnight memory retention, demonstrating a specific mechanism by which REM sleep enhances long-term memory.
Noxious radiant heat evokes bi-component nociceptive withdrawal reflexes in spinal cord injured humans-A clinical tool to study neuroplastic changes of spinal neural circuits.
Front Hum Neurosci
May 2023
Investigating nocifensive withdrawal reflexes as potential surrogate marker for the spinal excitation level may widen the understanding of maladaptive nociceptive processing after spinal cord injury (SCI). The aim of this prospective, explorative cross-sectional observational study was to investigate the response behavior of individuals with SCI to noxious radiant heat (laser) stimuli and to assess its relation to spasticity and neuropathic pain, two clinical consequences of spinal hyperexcitability/spinal disinhibition. Laser stimuli were applied at the sole and dorsum of the foot and below the fibula head.
View Article and Find Full Text PDF