Nano-second pulsed laser ablation of inconel 718 and MMPCD for simultaneous optimal ablation rate and surface quality.

This study investigates the ablation performance of Inconel 718, a nickel-based superalloy, and metal matrix polycrystalline diamond (MMPCD), a super composite, using a nano-second (ns) pulsed laser across a range of ablation conditions. Single trenches varying in energy fluence and scanning speeds were created, analyzing the experimental responses in terms of ablation rate and surface roughness. Using regression techniques, models were developed to understand these relationships.

Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows methylation is reset during stem cell reprogramming.

DNA methylation is an important epigenetic mechanism that helps define and maintain cellular functions. It is influenced by many factors, including environmental exposures, genotype, cell type, sex, and aging. Since age is the primary risk factor for developing neurodegenerative diseases, it is important to determine if aging-related DNA methylation is retained when cells are reprogrammed to an induced Pluripotent Stem Cell (iPSC) state.

AURA: Accelerating drug discovery with accuracy, utility, and rank-order assessment for data-driven decision making.

Biopharmaceutical companies generate a wealth of data, ranging from in silico physicochemical properties and machine learning models to both low and high-throughput in vitro assays and in vivo studies. To effectively harnesses this extensive data, we introduce a statistical methodology facilitated by Accuracy, Utility, and Rank Order Assessment (AURA), which combines basic statistical analyses with dynamic data visualizations to evaluate endpoint effectiveness in predicting intestinal absorption. We demonstrated that various physicochemical properties uniquely influence intestinal absorption on a project-specific basis, considering factors like intestinal efflux, passive permeability, and clearance.

Atmospheric rivers cause warm winters and extreme heat events.

Atmospheric rivers (ARs) are narrow regions of intense water vapour transport in the Earth's atmosphere. These transient phenomena carry water from the subtropics to the mid-latitudes and polar regions, making up the majority of polewards moisture transport and exerting control on the precipitation and water resources in many regions. In addition to transporting moisture, ARs also transport heat, but the impact of this transport on global near-surface air temperatures has not yet been characterized.