Publications by authors named "S Schofield"
Background: Heart rate variability (HRV) is governed by of sympathetic and parasympathetic regulatory systems. Post-Traumatic Stress Disorder (PTSD) may influence these systems and consequently affect cardiovascular functioning.
Methods: The sample consisted of 860 UK male military personnel approximately half of who had sustained physical combat injuries in Afghanistan.
To ensure specificity, loading of the sense strand of small interfering RNAs (siRNAs) into RISC must be inhibited. We show here that siRNAs with 5'- and 6'-morpholino LNA residues or 6'-OH-LNA at the 5' terminus of a fully phosphodiester sense strand resulted in metabolically stable siRNAs with a potency and a duration of action in mice that were greater than those of an siRNA in which the 5' terminus of the sense strand has two terminal phosphorothioate linkages and regular LNA.
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- Traumatic brain injury (TBI) is prevalent among military personnel and is linked to an increased risk of dementia, with the ADVANCE-TBI study focusing on the neurological effects of major battlefield trauma using blood biomarkers like NfL and GFAP.
- The study involved 1,145 servicemen and veterans, where TBI was identified in 16.9% of those exposed to major trauma, revealing significant mental health issues such as depression, anxiety, and PTSD, alongside impaired mobility and quality of life.
- Elevated GFAP levels were found post-TBI, particularly in more severe cases, indicating a correlation with mental health challenges and increased unemployment, demonstrating the long-term impact of TBI on military personnel.
Social support is a key determinant of mental health across multiple populations and contexts. Little is known about social support among UK (ex-)military personnel, especially those with combat injuries following deployment to Afghanistan. This study aimed to investigate the level of perceived social support and its associations with mental health among injured and uninjured UK (ex-)military personnel.
View Article and Find Full Text PDFBackground: Heart rate variability (HRV) is a marker of autonomic function. However, the reliability of short-term HRV measurement in individuals with combat-related traumatic injury (CRTI) remains undetermined.
Methods: An intra- and inter-rater reliability study was conducted using a subsample (n = 35) of British servicemen with CRTI enrolled in the ongoing ADVANCE study.