Publications by authors named "S Schlesinger"
Introduction: There is currently limited information regarding the association between the modified Nutrition Risk in Critically Ill (mNUTRIC) score, nutrition delivery and clinical outcomes in critically ill patients admitted to the intensive care unit (ICU) section.
Methods And Analysis: The Isfahan-ICU study is a multicentre, prospective observational cohort study that will be conducted on critically ill adults treated in the trauma or medical ICU sections of six hospitals to investigate whether clinical outcomes, including length of ICU stay and 30-day survival, vary by the mNUTRIC score at admission or the 7-day nutrition delivery. This paper outlines the Isfahan-ICU study protocol approved by the ethics committee of Isfahan University of Medical Sciences, Iran.
Aims: Two prerequisites must be met for the precision treatment approach to be beneficial for treated individuals. First, there must be treatment heterogeneity; second, in case of treatment heterogeneity, clinical predictors to identify people who would benefit from one treatment more than from others must be available. There is an established meta-regression approach to assess these two prerequisites that relies on measuring the variability of a clinical outcome after treatment in placebo-controlled randomised trials.
View Article and Find Full Text PDFIn patients with out-of-hospital cardiac arrest (OHCA) who attain return of spontaneous circulation (ROSC), rearrest while in the prehospital setting represents a significant barrier to survival. To date, there are limited data to guide prehospital emergency medical services (EMS) management immediately following successful resuscitation resulting in ROSC and prior to handoff in the emergency department. Post-ROSC care encompasses a multifaceted approach including hemodynamic optimization, airway management, oxygenation, and ventilation.
View Article and Find Full Text PDFArticle Synopsis
- Sarcopenia, a muscle-wasting syndrome, is prevalent among older patients with advanced colorectal cancer and is exacerbated by chemotherapy, leading to increased toxicity, reduced quality of life, and lower survival rates.
- This review systematically evaluated existing studies on the effects of physical activity and nutritional interventions on muscle mass specifically in patients with advanced colorectal cancer, identifying gaps in research focused on this demographic.
- Out of twelve studies reviewed, most reported heterogenous interventions, with a few demonstrating benefits from protein supplementation, aerobic exercise, and resistance training, though challenges included low recruitment rates and moderate to high risk of bias.
Evaluating the current breadth of randomized control trials on cardiac arrest: A scoping review.
J Am Coll Emerg Physicians Open
October 2024
Objectives: Despite the significant disease burden due to cardiac arrest, there is a relative paucity of randomized controlled trials (RCTs) to inform definitive management. We aimed to evaluate the current scope of cardiac arrest RCTs published between 2015 and 2022.
Methods: We conducted a search in October 2023 of MEDLINE, Embase, and Web of Science for cardiac arrest RCTs.