Publications by authors named "S Schache"
Article Synopsis
- Deiodinases (DIO1, DIO2, and DIO3) are crucial enzymes in the regulation of thyroid hormones, which affect energy metabolism, development, and various bodily functions, but can be disrupted by environmental factors and diseases.
- Current treatments for thyroid issues mainly use a DIO1-inhibitor, while specific inhibitors for DIO2 and DIO3 are limited, highlighting a gap in pharmacological options, especially for cancer therapy where DIO3 may promote tumor growth.
- A newly developed nonradioactive screening assay allows for improved high-throughput testing of all three human DIO isoenzymes, facilitating the identification of specific inhibitors for potential therapeutic use.
Serum glycogen phosphorylase activity as one of the sensitive indicators for the diagnosis of acute heart infarction was determined at 216 healthy probands using a standardized fluorometric procedure with a detection range from 0.03 to 6 nmol/s x l serum. Basal activity was averaged at 1.
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