Publications by authors named "S Saul"
Cigarette smoking confers additional risk from influenza. This study assessed the effect of smoking on humoral immune response to influenza vaccine. Adults ≥50 y of age were enrolled during the 2011-2016 influenza vaccination seasons in an observational prospective study.
View Article and Find Full Text PDFObjectives: Gastrointestinal symptoms can occur following pediatric solid organ transplantation (SOT), and a subset of children will develop chronic inflammatory bowel disease (IBD) posttransplant. The goal of this study was to characterize patients who developed IBD following SOT, their treatment modalities, and clinical course.
Methods: A retrospective review was performed of electronic medical records of patients 0-18 years of age who underwent heart, kidney, liver, or intestinal transplantation at our center from January 2009 to April 2019.
Article Synopsis
- The Mediterranean diet is beneficial for patients with inflammatory bowel disease (IBD), and culinary medicine can enhance dietary education and cooking skills.
- A survey of 112 young people with IBD revealed most were interested in the Mediterranean diet, but their adherence scores were mainly average or poor.
- After participating in cooking classes, there was a significant increase in diet quality scores over three months, and nearly all participants would recommend the classes to others, although some barriers to diet adoption remained.
Article Synopsis
- Human parainfluenza virus type 3 (HPIV3) is a significant respiratory virus in children, and currently, there are no vaccines or antiviral treatments available for it.
- Researchers created live-attenuated vaccine candidates by modifying specific genes of HPIV3 through a technique called codon-pair deoptimization (CPD), resulting in 12 different virus variants.
- Some modifications, particularly of the fusion (F) and hemagglutinin-neuraminidase (HN) proteins, not only reduced virus replication in cell cultures and animal models but also successfully triggered a strong immune response, indicating potential for effective vaccine development.
In search for broad-spectrum antivirals, we discovered a small molecule inhibitor, RMC-113, that potently suppresses the replication of multiple RNA viruses including SARS-CoV-2 in human lung organoids. We demonstrated selective dual inhibition of the lipid kinases PIP4K2C and PIKfyve by RMC-113 and target engagement by its clickable analog. Advanced lipidomics revealed alteration of SARS-CoV-2-induced phosphoinositide signature by RMC-113 and linked its antiviral effect with functional PIP4K2C and PIKfyve inhibition.
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