Publications by authors named "S Satpathy"

Background: Establishing and maintaining gamma knife facility incurs significant costs, mandating healthcare institutions to meticulously assess financial implications for sustainability.

Methods: This study explores the financial implications of setting up and operating a Gamma Knife facility, with an aim to ascertain user charges for achieving breakeven. The study was conducted from January to June 2019 at the largest neurosurgery centre of an Institute of National Importance (INI), in Delhi, India.

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Article Synopsis
  • The study presents an optimized workflow for analyzing formalin-fixed, paraffin-embedded (FFPE) patient tissues to uncover molecular insights linked to clinical outcomes, utilizing advanced techniques like Adaptive Focused Acoustics (AFA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS).
  • The method allows for the analysis of up to 96 samples, identifying between 8,000-10,000 unique proteins with a high level of quantitative accuracy (<20% median CVs).
  • Applied to lung adenocarcinoma FFPE blocks, the workflow demonstrates superior deep proteome coverage and efficiency, significantly contributing to biomarker discovery and proteomic research in archived samples.
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This study describes the deployment process of an AI-driven clinical decision support (CDS) system to support postpartum depression (PPD) prevention, diagnosis and management. Central to this CDS is an L2-regularized logistic regression model trained on electronic health record (EHR) data at an academic medical center, and subsequently refined through a broader dataset from a consortium to ensure its generalizability and fairness. The deployment architecture leveraged Microsoft Azure to facilitate a scalable, secure, and efficient operational framework.

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Plastic pollutants create health crises like physical damage to tissues, upset reproductive processes, altered behaviour, oxidative stress, neurological disorders, DNA damage, gene expression, and disrupt physiological functions, as the biosphere accumulates them inadvertently through the food web. Water resources have become the generic host of plastic wastes irrespective of their particle size, resulting in widespread distribution in aquatic environments. The pre-treatment step of the traditional water treatment process can easily remove coarse-sized plastic wastes.

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Article Synopsis
  • Atypical parathyroid tumor (APT) is a rare type of parathyroid gland neoplasm with unclear criteria for malignancy, making diagnosis challenging due to similarities with other tumors.
  • A case involving a 49-year-old male with hyperparathyroidism shows elevated calcium and parathyroid hormone levels, but pre-operative evaluations did not definitively categorize the tumor.
  • The final diagnosis of APT was made post-surgery after histopathological analysis revealed signs of capsular invasion without clear evidence of malignancy, emphasizing the need for awareness of these tumors in clinical settings.
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