Publications by authors named "S Satomi"
The present study involves the precise identification and safety evaluation of KB1733, previously identified using 16S rRNA analysis, through whole-genome sequencing, phenotypic analysis, and preclinical toxicity studies. Analyses based on the genome sequencing data confirm the identity of KB1733 as and show that the genes related to vancomycin resistance are only present on the chromosome, while no virulence factor genes are present on the chromosome or plasmid. Phenotypic analyses of antibiotic resistance and hemolytic activity also indicated no safety concerns.
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- Previous research confirmed that oral pulmonary vasodilators are beneficial for treating pulmonary hypertension (PH) in dogs, yet there was no direct comparison of their hemodynamic effects.
- This study compared the effects of beraprost sodium (15 µg/kg), sildenafil (1.0 mg/kg), and their combination on dogs with induced mitral regurgitation using heart catheterization and echocardiography.
- Results showed that both drugs improved heart function, with sildenafil showing stronger pulmonary effects but also risking increased left-heart pressure; however, their combination provided the best overall results without negative impacts on heart size or pressure indicators.
Background: Hereditary angioedema (HAE), a genetic disorder caused by C1-inhibitor deficiency or dysfunction, may cause mucosal edema in the upper airway during tracheal intubation and extubation.
Case Report: A 57-year-old man with HAE and a history of laryngeal edema, scheduled to undergo cervical laminoplasty under general anesthesia. General anesthesia was induced by continuous injection of remimazolam and remifentanil, during which manual mask ventilation and intubation were performed without difficulty.
An 8-year-old Leonberger receiving immunosuppressive treatment with clinical signs of acute dyspnea, cyanosis, and difficulty standing was referred to our institution (Day 1). Treatment including oxygen, clopidogrel, and low-molecular-weight heparin was initiated for suspected pulmonary thrombosis. However, exertional dyspnea persisted until Day 10, and increased tricuspid regurgitation velocity, pulmonary vascular resistance, and McConnell's signs also were observed.
View Article and Find Full Text PDFWe thank the authors for their insightful and thoughtful commentary on our recent publication [...
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