Effect of ketamine on anxiety: findings from the Ketamine for Adult Depression Study.

Background: Anxiety disorders and treatment-resistant major depressive disorder (TRD) are often comorbid. Studies suggest ketamine has anxiolytic and antidepressant properties.

Aims: To investigate if subcutaneous racemic ketamine, delivered twice weekly for 4 weeks, reduces anxiety in people with TRD.

Identifying predictors of sodium-glucose cotransporter 2 inhibitor and glucagon-like peptide 1 receptor agonist use in hospital among adults with diabetes.

Aims: To identify factors associated with use of novel diabetes medications among patients hospitalized under general internal medicine.

Methods: We conducted a cohort study of patients with type 2 diabetes mellitus (T2DM) hospitalized in Ontario, Canada between 2015 and 2020. We evaluated the patient- and physician-level factors associated with sodium-glucose cotransporter 2 inhibitor (SGLT2) and glucagon-like peptide 1 receptor agonist (GLP1R) use using a multivariable logistic regression model.

Selective learning for sensing using shift-invariant spectrally stable undersampled networks.

The amount of data collected for sensing tasks in scientific computing is based on the Shannon-Nyquist sampling theorem proposed in the 1940s. Sensor data generation will surpass 73 trillion GB by 2025 as we increase the high-fidelity digitization of the physical world. Skyrocketing data infrastructure costs and time to maintain and compute on all this data are increasingly common.

Isolation, Characterization, In Vitro and In Silico Assessment of Undescribed Bioactive Constituents from L. Heartwood.

heartwood is well acknowledged for its medicinal properties and use in the furniture and handicraft industries. Owing to its medicinal properties, the present investigation aims to isolate and characterize the secondary metabolites from the heartwood. The investigation led to the isolation of one undescribed dehydropterocarpan and eleven known compounds.