Publications by authors named "S Saraswat"
Article Synopsis
- Obesity in older adults is prevalent and contributes to chronic inflammation, affecting the health of older populations.
- Research suggests that obesity alters the immune response, particularly influencing T-cell function and the effectiveness of anti-inflammatory drugs like metformin.
- Data reveal that metformin does not improve immune cell function in obese older adults as it does in lean individuals, indicating that obesity complicates the body's inflammatory response and must be considered in clinical studies of geroprotective treatments.
Breast cancer is a complicated malignancy and is known as the most common cancer in women. Considerable experiments have been devoted to explore the basic impacts of the tumor stroma, particularly the extracellular matrix (ECM) and stromal components, on tumor growth and resistance to treatment. ECM is made up of an intricate system of proteins, glycosaminoglycans, and proteoglycans, and maintains structural support and controls key signaling pathways involved in breast tumors.
View Article and Find Full Text PDFDendritic cells (DCs) are critical players at the intersection of innate and adaptive immunity, making them ideal candidates for anticancer vaccine development. DC-based immunotherapies typically involve isolating patient-derived DCs, pulsing them with tumor-associated antigens (TAAs) or tumor-specific antigens (TSAs), and utilizing maturation cocktails to ensure their effective activation. These matured DCs are then reinfused to elicit tumor-specific T-cell responses.
View Article and Find Full Text PDFArticle Synopsis
- Periodontitis (PD) is shown to influence systemic inflammation related to both obesity and type 2 diabetes (T2D), but the effects vary between the two conditions.
- An analysis of blood samples indicated that PD shifts inflammation caused by T cells in obesity and modifies myeloid cell inflammation in T2D, demonstrating a complex, bidirectional relationship between these diseases.
- The study emphasizes the need to examine both oral health and metabolic status beyond just obesity to fully understand how PD interacts with systemic inflammatory diseases like T2D, particularly highlighting differences based on the stage of PD.
Aim: Peri-implant mucositis, a dysbiosis-driven inflammatory disease, is a precursor to peri-implantitis, underscoring the need for early disease management. Therefore, we investigated the efficacy of glycine powder in resolving clinical inflammation and restoring host-microbial homeostasis.
Methods: Thirty subjects were randomized to receive either glycine powder air-abrasive debridement or ultrasonic instrumentation.