Publications by authors named "S Santana"
Preclinical and/or clinical studies have demonstrated the potential of Ivermectin (IVM) for malaria control. In order to improve its antiplasmodial activity and build on previous knowledge, we have designed a third generation of hybrid molecules in which selected pharmacophores were appended to the IVM macrolide, while retaining one or both sugar moieties at the C-13 position. Moreover, we synthesized IVM hybrids that contain structural features of potent IVM metabolites.
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- Agricultural pests directly harm crops and can also indirectly damage them by spreading harmful pathogens, affecting crop yield and quality.
- Mites, especially the two-spotted spider mite, are a significant concern in agriculture due to their widespread infestation of numerous plant species and potential contributions to agricultural losses.
- The study aimed to explore the virome of these mites using RNA sequencing, uncovering 20 viral sequences, including new and related strains that could impact food security and complicate pest management strategies.
Background: Hypovitaminosis D may be common in tropical countries and is linked to disorders of phospho-calcium metabolism, rickets, muscle pain, immune system deficiencies, and increased susceptibility to microbial infections.
Objective: To assess the prevalence of hypovitaminosis D in apparently healthy university workers in Loja, Ecuador.
Methods: A cross-sectional study was completed in a private Ecuadorian university from May 2023 to September 2023, involving 440 participants.
Effects of osteopathic manipulative treatment associated with transcranial direct current stimulation in individuals with chronic low back pain: A double-blind, randomised placebo-controlled trial.
Clin Rehabil
December 2024
Objective: To evaluate the effectiveness of osteopathic manipulative treatment (OMT) associated with transcranial direct current stimulation (tDCS) in reducing pain, disability, and improving quality of life in participants with non-specific chronic low back pain.
Design: A randomised double-blind clinical trial.
Setting: Clinical outpatient unit.
Understanding the effects of mining activities on Amazonian streams and their impact on aquatic communities is of paramount importance in the current context of resource overexploitation in society. In this study, we assessed the significance of the environment and interspecific interactions on the organization patterns of semiaquatic insect species in a mineral extraction region in the eastern Amazon. We utilized the morpho functional characteristics of 22 species from the suborder Gerromorpha (Heteropteran), considering both the abundance and sexual dimorphism of these species.
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