Nitrate Esters of Heteroaromatic Compounds as Candida albicans CYP51 Enzyme Inhibitors.

Four heteroaromatic compounds bearing nitrate esters were selected using a virtual-screening procedure as putative sterol 14α-demethylase (CYP51) Candida albicans inhibitors. Compounds were examined for their inhibition on C. albicans growth and biofilm formation as well as for their toxicity.

[Intratympanic corticosteroid perfusion in the therapy of Meniere's disease].

Introduction: Over the last two decades the intratympanic perfusion of corticosteroids has been used as a minimally invasive surgical therapy of Meniere's disease. According to experimental studies the antiinflammatory, immunoprotective, antioxidant and neuroprotective role of the locally perfused corticosteroids was noticed in the inner ear structures. The recovery of action potentials in the cells of the Corti organ was confirmed as well as a decreased expression of aquaporine-1, a glycoprotein responsible for labyrinth hydrops and N and K ions derangement.

[Kiss-induced severe anaphylactic reactions].

Introduction: Ingestion is the principal route for food allergens to trigger allergic reaction in atopic persons. However, in some highly sensitive patients severe symptoms may develop upon skin contact and by inhalation. The clinical spectrum ranges from mild facial urticaria and angioedema to life-threatening anaphylactic reactions.

[Role of immune factors in the pathogenesis of secretory otitis media].

Authors have been analysed the main role of immunological factors in complex pathogenesis of secretory otitis media. Data from recent literature and data from studies that were conducted in ENT city hospital in Belgrade were reviewed. The mucosa of the middle esr belong to the nasopharyngeal associated lymphoid tissue (NALT).

[Carcinoembryonic antigen in chronic otitis media with cholesteatoma].

Introduction: Carcinoembryonic antigen (CEA) is a cell surface glycoprotein and member of immunoglobuline superfamily. Recent studies pointed out that this glycoprotein also belonged to the family of intercellular adhesive molecules (ICAMs). The presence and increased expression of CEA is noticed in chronic inflammation of the skin, gall bladder and extrahepatic biliary tract.