Mast cells in chronic inflammation of the middle ear mucosa.

Aim Of The Study: The number, distribution and degranulation frequency of mast cells have been studied in the middle ear mucosa biopsies of patients with chronic otitis media.

Materials And Methods: The pathohistological analysis has been performed on 115 biopsy specimens, taken intraoperatively from the different regions of the middle ear cleft in 27 patients with chronic otitis media and in 15 children with otomastoiditis which occurred during the treatment of secretory otitis media. Mast cells were identified on the basis of metachromatic staining for histamine and heparin granules.

Carcinoembryonic antigen in chronic otitis media: an immunohistochemical study of the middle ear mucosa.

Carcinoembryonic antigen (CEA) has an important role as a tumor marker and also as a cell adhesion molecule. The expression and the role of CEA in chronic inflammation of middle ear mucosa has not been studied previously. Immunohistochemical analysis with monoclonal antibodies against human CEA was performed in order to detect CEA in formalin fixed and paraffin embedded biopsy specimens of middle ear mucosa in chronic otitis media.

[Mastocytes in chronic inflammation of middle ear mucosa].

Introduction: Pathohistological studies have shown that in secretory otitis media an increased number of mast cells have been found in mucosa of the middle ear and an increased level of histamine in the cavity of the middle ear. The aim of this study was to analyse the distribution and functional state of mast cells in middle ear mucosa biopsies in patients with chronic otitis media.

Material And Methods: The pathohistological analysis was performed on 118 biopsy specimens of mucosa of the middle ear.

[Surgical treatment of secretory otitis media: persistent perforation as a rare complication].

Introduction: The persistent perforation of the ear drum may appear as a complication after spontaneous or instrumental elimination of ventilatory tubes during surgical management of secretory otitis media. According to recent literature data its incidence can vary in an average interval from 0.5 to 3.

[Tympanosclerosis of the tympanic membrane].

The structure of the tympanosclerotic plaques of the tympanic membrane was examined by using the scanning electron microscope. Studies were carried out on specimens of the tympanosclerotic plaques obtained during surgery in 15 patients for chronic middle ear inflammation. It was found that tympanosclerotic plaques contained fibrous fibers of different densities, distribution and calcification, and without cellular elements.